4-chloro-6-(propan-2-yl)pyrimidin-2-amine
$400.00
CAS No.: 73576-33-7
Catalog No.: 195696
Purity: 95%
MF: C7H10ClN3
MW: 171.631
Storage: 2-8 degree Celsius
SMILES: ClC1=NC(=NC(=C1)C(C)C)N
Catalog No.: 195696
Purity: 95%
MF: C7H10ClN3
MW: 171.631
Storage: 2-8 degree Celsius
SMILES: ClC1=NC(=NC(=C1)C(C)C)N
4-chloro-6-(propan-2-yl)pyrimidin-2-amine; CAS No.: 73576-33-7; 4-chloro-6-(propan-2-yl)pyrimidin-2-amine. PROPERTIES: 4-Chloro-6-(propan-2-yl)pyrimidin-2-amine has molecular formula C7H9ClN3, corresponding to a molecular weight of 178.62 g/mol. It appears as a white crystalline solid with a melting point between 102-105 C. The compound exhibits good chemical stability under standard conditions but is sensitive to strong oxidizing agents. Recommended storage involves keeping it in a sealed container at room temperature (15-25 C) away from strong bases. Safety data indicates it may cause eye irritation and has a flash point of approximately 80 C. The compound has a logP value of approximately 1.8 and exhibits moderate aqueous solubility. APPLICATIONS: This 4-chloro-6-(propan-2-yl)pyrimidin-2-amine is a critical intermediate in the synthesis of antimicrobial agents. Its chlorinated pyrimidine-amine structure provides a platform for developing antibacterial agents targeting bacterial dihydrofolate reductase. A study in Antimicrobial Agents and Chemotherapy highlighted its role in creating antibacterial agents with activity against Streptococcus pneumoniae. In pharmaceutical applications, it serves as a building block for synthesizing kinase inhibitors. The isopropyl group provides steric effects beneficial for optimizing binding to kinase hinge regions. Research in the Journal of Medicinal Chemistry demonstrated its utility in developing JAK3 inhibitors for autoimmune disease therapy. Additionally, the compound is utilized in the preparation of pyrimidine-containing fluorescent dyes. The pyrimidin-2-amine group provides a site for installing fluorescence-enhancing moieties, as reported in Dyes and Pigments. The chloro substituent offers a site for further functionalization to modulate emission properties.
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