4-(6-bromopyrazin-2-yl)morpholine
$300.00
CAS No.: 848841-62-3
Catalog No.: 196333
Purity: 95%
MF: C8H10BrN3O
MW: 244.092
Storage: 2-8 degree Celsius
SMILES: BrC1=CN=CC(=N1)N1CCOCC1
Catalog No.: 196333
Purity: 95%
MF: C8H10BrN3O
MW: 244.092
Storage: 2-8 degree Celsius
SMILES: BrC1=CN=CC(=N1)N1CCOCC1
4-(6-bromopyrazin-2-yl)morpholine; CAS No.: 848841-62-3; 4-(6-bromopyrazin-2-yl)morpholine. PROPERTIES: This compound presents a 4-(6-bromopyrazin-2-yl)morpholine structure, combining a bromopyrazine group and a morpholine ring system. It typically appears as a white to off-white crystalline solid with a molecular weight of approximately 233.0 g/mol (C6H8BrN3O). The melting point ranges between 110-115 C, and it exhibits moderate solubility in common organic solvents like DMSO and DMF while being sparingly soluble in water. Proper storage requires a tightly sealed container in a cool, dry place. Safety considerations include wearing appropriate PPE. It is classified as a skin and eye irritant (GHS07) with the hazard statement H315-H319. APPLICATIONS: 4-(6-Bromopyrazin-2-yl)morpholine serves as a specialized intermediate in pharmaceutical research. Its 4-(6-bromopyrazin-2-yl)morpholine structure enables diverse reactivity patterns, including palladium-catalyzed cross-coupling reactions at the bromine position and nucleophilic substitution at the morpholine ring. In medicinal chemistry, it is used to develop bioactive molecules targeting kinases, proteases, and G protein-coupled receptors. The bromine atom provides a handle for introducing aryl, vinyl, or heterocyclic substituents. This compound also functions as a building block in the synthesis of fluorescent dyes and bioconjugation reagents. Academic studies utilize it as a model system in Medicinal Chemistry journals, focusing on optimizing the 4-(6-bromopyrazin-2-yl)morpholine scaffold for improved biological activity and target engagement.
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