3-amino-5-chloropyrazine-2-carboxylic acid
$300.00
CAS No.: 1260663-68-0
Catalog No.: 196331
Purity: 95%
MF: C5H4ClN3O2
MW: 173.559
Storage: 2-8 degree Celsius
SMILES: NC=1C(=NC=C(N1)Cl)C(=O)O
Catalog No.: 196331
Purity: 95%
MF: C5H4ClN3O2
MW: 173.559
Storage: 2-8 degree Celsius
SMILES: NC=1C(=NC=C(N1)Cl)C(=O)O
3-amino-5-chloropyrazine-2-carboxylic acid; CAS No.: 1260663-68-0; 3-amino-5-chloropyrazine-2-carboxylic acid. PROPERTIES: This compound presents a 3-amino-5-chloropyrazine-2-carboxylic acid structure, combining an amino group, a chloro substituent, and a pyrazine carboxylic acid moiety. It typically appears as a white to off-white crystalline solid with a molecular weight of approximately 175.0 g/mol (C5H4ClN3O2). The melting point ranges between 180-185 C, and it exhibits moderate solubility in common organic solvents like ethanol, methanol, and DMSO while being sparingly soluble in water. Proper storage requires a tightly sealed container in a cool, dry place. Safety considerations include wearing appropriate PPE. It is classified as a skin and eye irritant (GHS07) with the hazard statement H315-H319. APPLICATIONS: 3-Amino-5-chloropyrazine-2-carboxylic acid serves as a specialized intermediate in pharmaceutical research. Its 3-amino-5-chloropyrazine-2-carboxylic acid structure enables diverse reactivity patterns, including esterification, amide bond formation, and nucleophilic substitution at the pyrazine ring. In medicinal chemistry, it is used to develop bioactive molecules targeting kinases, proteases, and G protein-coupled receptors. The amino and chloro groups provide diverse substitution patterns for creating structural analogs. This compound also functions as a building block in the synthesis of fluorescent dyes and bioconjugation reagents. Academic studies utilize it as a model system in Medicinal Chemistry journals, focusing on optimizing the 3-amino-5-chloropyrazine-2-carboxylic acid scaffold for improved biological activity and pharmacokinetic properties.
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