2-bromo-1-(pyrazin-2-yl)ethanone
$300.00
CAS No.: 132426-19-8
Catalog No.: 196345
Purity: 95%
MF: C6H5BrN2O
MW: 201.023
Storage: 2-8 degree Celsius
SMILES: BrCC(=O)C1=NC=CN=C1
Catalog No.: 196345
Purity: 95%
MF: C6H5BrN2O
MW: 201.023
Storage: 2-8 degree Celsius
SMILES: BrCC(=O)C1=NC=CN=C1
2-bromo-1-(pyrazin-2-yl)ethanone; CAS No.: 132426-19-8; 2-bromo-1-(pyrazin-2-yl)ethanone. PROPERTIES: This compound presents a 2-bromo-1-(pyrazin-2-yl)ethanone structure, combining a bromine atom, a pyrazine ring, and an ethanone group. It typically appears as a white to off-white crystalline solid with a molecular weight of approximately 213.0 g/mol (C6H4BrN3O). The melting point ranges between 90-95 C, and it exhibits moderate solubility in common organic solvents like ethyl acetate, dichloromethane, and tetrahydrofuran while being sparingly soluble in water. Proper storage requires a tightly sealed container in a cool, dry place. Safety considerations include wearing appropriate PPE. It is classified as a skin and eye irritant (GHS07) with the hazard statement H315-H319. APPLICATIONS: 2-Bromo-1-(pyrazin-2-yl)ethanone serves as a specialized intermediate in pharmaceutical research. Its 2-bromo-1-(pyrazin-2-yl)ethanone structure enables diverse reactivity patterns, including nucleophilic substitution at the bromine atom and the ketone carbonyl. In medicinal chemistry, it is used to develop bioactive molecules targeting kinases, proteases, and G protein-coupled receptors. The bromine atom provides a handle for introducing aryl, vinyl, or heterocyclic substituents. This compound also functions as a building block in the synthesis of fluorescent dyes and bioconjugation reagents. Academic studies utilize it as a model system in Medicinal Chemistry journals, focusing on optimizing the 2-bromo-1-(pyrazin-2-yl)ethanone scaffold for improved biological activity and target engagement.
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