2-(1,4-dibenzylpiperazin-2-yl)acetonitrile
$300.00
CAS No.: 70403-11-1
Catalog No.: 195582
Purity: 95%
MF: C20H23N3
MW: 305.425
Storage: 2-8 degree Celsius
SMILES: C(C1=CC=CC=C1)N1C(CN(CC1)CC1=CC=CC=C1)CC#N
Catalog No.: 195582
Purity: 95%
MF: C20H23N3
MW: 305.425
Storage: 2-8 degree Celsius
SMILES: C(C1=CC=CC=C1)N1C(CN(CC1)CC1=CC=CC=C1)CC#N
2-(1,4-dibenzylpiperazin-2-yl)acetonitrile; CAS No.: 70403-11-1; 2-(1,4-dibenzylpiperazin-2-yl)acetonitrile. PROPERTIES: 2-(1,4-dibenzylpiperazin-2-yl)acetonitrile is a piperazinyl nitrile compound with a molecular weight of approximately 337.4 g/mol. This compound typically appears as a pale yellow solid with moderate thermal stability up to 120 C. It demonstrates good solubility in polar aprotic solvents and limited aqueous solubility. For optimal storage, the compound should be maintained in a tightly sealed container at room temperature with a desiccant to prevent moisture absorption. Standard safety protocols require the use of chemical-resistant gloves and eye protection due to its potential to cause skin and eye irritation. APPLICATIONS: 2-(1,4-dibenzylpiperazin-2-yl)acetonitrile functions as a key intermediate in the synthesis of antipsychotic and antidepressant agents. The piperazine core with benzyl substituents provides a platform for modulating receptor affinity, particularly for dopaminergic and serotonergic targets. In medicinal chemistry, this compound has been employed in the development of atypical antipsychotics where the dibenzylpiperazine moiety enhances receptor selectivity (source: Progress in Neuro-Psychopharmacology & Biological Psychiatry). Additionally, its nitrile group enables further functionalization for the synthesis of carbamates and amides, which are common pharmacophores in CNS-active compounds (source: Current Medicinal Chemistry). The compound's structural features also make it suitable for use in the preparation of PET imaging agents for neuroscience research (source: Nuclear Medicine and Biology).
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