![ethyl 2-(5-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)acetate](https://www.chemshuttle.com/media/catalog/product/cache/31dbf0bffbfa69a5826a72cec9a446de/1/9/195497_2.jpg)
1-tert-butyl 3-ethyl piperazine-1,3-dicarboxylate
$360.00
CAS No.: 183742-29-2
Catalog No.: 195581
Purity: 95%
MF: C12H22N2O4
MW: 258.318
Storage: 2-8 degree Celsius
SMILES: N1(CC(NCC1)C(=O)OCC)C(=O)OC(C)(C)C
Catalog No.: 195581
Purity: 95%
MF: C12H22N2O4
MW: 258.318
Storage: 2-8 degree Celsius
SMILES: N1(CC(NCC1)C(=O)OCC)C(=O)OC(C)(C)C
1-tert-butyl 3-ethyl piperazine-1,3-dicarboxylate; CAS No.: 183742-29-2; 1-tert-butyl 3-ethyl piperazine-1,3-dicarboxylate. PROPERTIES: 1-tert-butyl 3-ethyl piperazine-1,3-dicarboxylate is a piperazine derivative with a molecular weight of approximately 268.3 g/mol. This compound typically exists as a white crystalline powder with moderate stability under ambient conditions. It demonstrates good solubility in polar organic solvents and limited aqueous solubility. For long-term storage, the compound should be kept in a tightly sealed container at temperatures below 10 C to prevent potential hydrolysis of the ester groups. Standard safety precautions include avoiding exposure to open flames due to its moderate flammability and using appropriate respiratory protection during handling. APPLICATIONS: 1-tert-butyl 3-ethyl piperazine-1,3-dicarboxylate serves as a protected piperazine building block in medicinal chemistry. The diester protection strategy allows for selective deprotection and functionalization of the piperazine ring. In pharmaceutical synthesis, this compound has been utilized in the preparation of HIV integrase inhibitors where the piperazine scaffold mediates critical protein interactions (source: Journal of Medicinal Chemistry). Additionally, its application extends to the synthesis of CNS-active compounds, where the piperazine ring contributes to blood-brain barrier penetration (source: European Journal of Medicinal Chemistry). The compound's utility in solid-phase synthesis further enhances its application in combinatorial chemistry approaches for lead compound discovery (source: Journal of Combinatorial Chemistry).
Reviews
Write Your Own Review