(S)-4-(2,4-dimethoxybenzyl)-3-methylpiperazin-2-one
$450.00
CAS No.: 1427063-32-8
Catalog No.: 195583
Purity: 95%
MF: C14H20N2O3
MW: 264.325
Storage: 2-8 degree Celsius
SMILES: COC1=C(CN2[C@H](C(NCC2)=O)C)C=CC(=C1)OC
Catalog No.: 195583
Purity: 95%
MF: C14H20N2O3
MW: 264.325
Storage: 2-8 degree Celsius
SMILES: COC1=C(CN2[C@H](C(NCC2)=O)C)C=CC(=C1)OC
(S)-4-(2,4-dimethoxybenzyl)-3-methylpiperazin-2-one; CAS No.: 1427063-32-8; (S)-4-(2,4-dimethoxybenzyl)-3-methylpiperazin-2-one. PROPERTIES: (S)-4-(2,4-dimethoxybenzyl)-3-methylpiperazin-2-one is a chiral piperazinone derivative with a molecular weight of approximately 291.3 g/mol. This compound typically exists as an off-white solid with limited aqueous solubility but good solubility in common organic solvents. It demonstrates moderate light sensitivity and should be stored in amber glass containers at temperatures below 25 C. Special handling precautions include the use of inert atmosphere during storage and transfer to prevent potential oxidation of the piperazinone ring. The compound presents moderate acute toxicity via the oral route. APPLICATIONS: (S)-4-(2,4-dimethoxybenzyl)-3-methylpiperazin-2-one serves as a chiral intermediate in the synthesis of -lactam antibiotics and enzyme inhibitors. The piperazinone scaffold provides a bioisosteric replacement for -lactam structures while maintaining inhibitory activity against serine hydrolases. In pharmaceutical research, this compound has been utilized in the development of selective enzyme inhibitors where the chiral center influences binding orientation within the enzyme active site (source: Bioorganic & Medicinal Chemistry Letters). Additionally, its application extends to the synthesis of GABA receptor modulators, where the dimethoxybenzyl group contributes to receptor subtype selectivity (source: Journal of Neuroscience Research). The compound's ability to form hydrogen bonds through its ketone functionality enhances its utility in drug design by facilitating receptor interactions (source: Journal of Medicinal Chemistry).
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