1-(3-methoxyphenyl)piperazine dihydrochloride
$300.00
CAS No.: 6968-76-9
Catalog No.: 196272
Purity: 95%
MF: C11H18Cl2N2O
MW: 265.184
Storage: 2-8 degree Celsius
SMILES: Cl.Cl.COC=1C=C(C=CC1)N1CCNCC1
Catalog No.: 196272
Purity: 95%
MF: C11H18Cl2N2O
MW: 265.184
Storage: 2-8 degree Celsius
SMILES: Cl.Cl.COC=1C=C(C=CC1)N1CCNCC1
1-(3-methoxyphenyl)piperazine dihydrochloride; CAS No.: 6968-76-9; 1-(3-methoxyphenyl)piperazine dihydrochloride. PROPERTIES: This compound presents a 1-(3-methoxyphenyl)piperazine dihydrochloride structure, combining a methoxyphenyl substituent and a piperazine ring, and presented as a dihydrochloride salt. It typically appears as a white to off-white crystalline solid with a molecular weight of approximately 229.2 g/mol (C11H16N2O {2HCl). The melting point ranges between 150-155 C, and it exhibits good solubility in water and common organic solvents like ethanol and methanol. Proper storage requires a tightly sealed container in a cool, dry place. Safety considerations include wearing appropriate PPE. It is classified as a skin and eye irritant (GHS07) with the hazard statement H315-H319. APPLICATIONS: 1-(3-Methoxyphenyl)piperazine dihydrochloride serves as a specialized intermediate in pharmaceutical research. Its 1-(3-methoxyphenyl)piperazine dihydrochloride structure enables diverse reactivity patterns, including nucleophilic substitution at the piperazine nitrogen and hydrogen bonding interactions through the methoxy group. In medicinal chemistry, it is used to develop bioactive molecules targeting kinases, proteases, and G protein-coupled receptors. The methoxyphenyl substituent provides steric and electronic effects that influence binding interactions with biological targets. This compound also functions as a building block in the synthesis of fluorescent dyes and bioconjugation reagents. Academic studies utilize it as a model system in Medicinal Chemistry journals, focusing on optimizing the 1-(3-methoxyphenyl)piperazine dihydrochloride scaffold for improved biological activity and target engagement.
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