tert-butyl morpholin-3-ylmethylcarbamate
$400.00
CAS No.: 169750-75-8
Catalog No.: 196258
Purity: 95%
MF: C10H20N2O3
MW: 216.281
Storage: 2-8 degree Celsius
SMILES: N1C(COCC1)CNC(OC(C)(C)C)=O
Catalog No.: 196258
Purity: 95%
MF: C10H20N2O3
MW: 216.281
Storage: 2-8 degree Celsius
SMILES: N1C(COCC1)CNC(OC(C)(C)C)=O
tert-butyl morpholin-3-ylmethylcarbamate; CAS No.: 169750-75-8; tert-butyl morpholin-3-ylmethylcarbamate. PROPERTIES: This compound features a tert-butyl morpholin-3-ylmethylcarbamate structure, combining a tert-butyl ester, a morpholine ring, and a carbamate group. It typically appears as a white to off-white crystalline solid with a molecular weight of approximately 237.3 g/mol (C11H20N2O3). The melting point ranges between 100-105 C, and it exhibits moderate solubility in common organic solvents like ethyl acetate, dichloromethane, and tetrahydrofuran while being sparingly soluble in water. Proper storage requires a tightly sealed container in a cool, dry place. Safety considerations include wearing appropriate PPE. It is classified as a skin and eye irritant (GHS07) with the hazard statement H315-H319. APPLICATIONS: tert-Butyl morpholin-3-ylmethylcarbamate serves as a valuable intermediate in pharmaceutical and chemical synthesis. Its tert-butyl morpholin-3-ylmethylcarbamate structure enables participation in various reactions, including ester hydrolysis, nucleophilic substitution at the carbamate group, and hydrogen bonding through the morpholine nitrogen. In medicinal chemistry, it is used to develop bioactive molecules targeting kinases, proteases, and G protein-coupled receptors. The tert-butyl ester provides temporary protection for the carboxylic acid, allowing sequential synthesis steps. This compound also functions as a building block in the synthesis of bioactive peptides and depsipeptides. Academic studies employ it as a model compound in Medicinal Chemistry journals, focusing on optimizing the tert-butyl morpholin-3-ylmethylcarbamate scaffold for improved biological activity and pharmacokinetic properties.
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