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4-(4-methylpiperidin-4-yl)morpholine hydrochloride; CAS No.: 930604-28-7; 4-(4-methylpiperidin-4-yl)morpholine hydrochloride. PROPERTIES: This compound features a 4-(4-methylpiperidin-4-yl)morpholine hydrochloride structure, combining a methylpiperidine group and a morpholine ring, and presented as a hydrochloride salt. It typically appears as a white to off-white crystalline solid with a molecular weight of approximately 209.3 g/mol (C10H19N2O {HCl). The melting point ranges between 150-155 C, and it exhibits good solubility in water and common organic solvents like ethanol and methanol. Proper storage requires a tightly sealed container in a cool, dry place. Safety considerations include wearing appropriate PPE. It is classified as a skin and eye irritant (GHS07) with the hazard statement H315-H319. APPLICATIONS: 4-(4-Methylpiperidin-4-yl)morpholine hydrochloride serves as a versatile intermediate in pharmaceutical and chemical synthesis. Its 4-(4-methylpiperidin-4-yl)morpholine hydrochloride structure allows for participation in various reactions, including nucleophilic substitution at the morpholine nitrogen and hydrogen bonding interactions through the piperidine group. In medicinal chemistry, it is used to develop bioactive molecules targeting G protein-coupled receptors and ion channels. The methylpiperidine group provides steric protection and metabolic stability. This compound also functions as a building block in the synthesis of bioactive peptides and depsipeptides. Academic studies employ it as a model compound in Medicinal Chemistry journals, focusing on optimizing the 4-(4-methylpiperidin-4-yl)morpholine hydrochloride scaffold for improved biological activity and pharmacokinetic properties.