4-(4-nitrobenzyl)morpholine
$400.00
CAS No.: 6425-46-3
Catalog No.: 196257
Purity: 95%
MF: C11H14N2O3
MW: 222.244
Storage: 2-8 degree Celsius
SMILES: [N+](=O)([O-])C1=CC=C(CN2CCOCC2)C=C1
Catalog No.: 196257
Purity: 95%
MF: C11H14N2O3
MW: 222.244
Storage: 2-8 degree Celsius
SMILES: [N+](=O)([O-])C1=CC=C(CN2CCOCC2)C=C1
4-(4-nitrobenzyl)morpholine; CAS No.: 6425-46-3; 4-(4-nitrobenzyl)morpholine. PROPERTIES: This compound presents a 4-(4-nitrobenzyl)morpholine structure, combining a nitro-substituted benzyl group and a morpholine ring system. It typically appears as a white to off-white crystalline solid with a molecular weight of approximately 237.2 g/mol (C12H15N3O2). The melting point ranges between 70-75 C, and it exhibits moderate solubility in common organic solvents like ethanol, methanol, and DMSO while being sparingly soluble in water. Proper storage requires a tightly sealed container in a cool, dry place. Safety considerations include wearing appropriate PPE. It is classified as a skin and eye irritant (GHS07) with the hazard statement H315-H319. APPLICATIONS: 4-(4-Nitrobenzyl)morpholine serves as a specialized intermediate in pharmaceutical research. Its 4-(4-nitrobenzyl)morpholine structure enables diverse reactivity patterns, including nucleophilic substitution at the benzyl position and reduction of the nitro group to amine. In medicinal chemistry, it is used to develop bioactive molecules targeting the central nervous system and inflammatory pathways. The nitro group can be converted to hydroxylamine or amine derivatives to explore structure-activity relationships. This compound also functions as a building block in the synthesis of fluorescent probes and bioconjugation reagents. Academic studies utilize it as a model system in Medicinal Chemistry journals, focusing on optimizing the 4-(4-nitrobenzyl)morpholine scaffold for improved biological activity and target engagement.
Reviews
Write Your Own Review