5-chloroisoquinoline-8-carboxylic acid
$600.00
CAS No.: 1935127-38-0
Catalog No.: 191957
Purity: 95%
MF: C10H6ClNO2
MW: 207.616
Storage: 2-8 degree Celsius
SMILES: ClC1=C2C=CN=CC2=C(C=C1)C(=O)O
Catalog No.: 191957
Purity: 95%
MF: C10H6ClNO2
MW: 207.616
Storage: 2-8 degree Celsius
SMILES: ClC1=C2C=CN=CC2=C(C=C1)C(=O)O
5-chloroisoquinoline-8-carboxylic acid; CAS No.: 1935127-38-0; 5-chloroisoquinoline-8-carboxylic acid. PROPERTIES: 5-chloroisoquinoline-8-carboxylic acid (CAS No.: 1935127-38-0) appears as a pale yellow crystalline solid with a melting point between 220-223 C. The compound features a chlorine atom at position 5 and a carboxylic acid at position 8 of the isoquinoline ring system. Its carboxylic acid group demonstrates typical acidity with a pKa around 3.6, while the chlorine substituent imparts moderate electron-withdrawing effects that enhance the compound's reactivity. Solubility characteristics reveal moderate dissolvability in polar organic solvents like DMSO and DMF, with limited water solubility due to the hydrophobic aromatic system. The substance is moisture-sensitive and prone to hydrolysis under basic conditions, necessitating storage in a tightly sealed container under nitrogen atmosphere at controlled temperature (15-25 C). Safety protocols recommend N95 respiratory protection, chemical-resistant gloves, and eye protection due to potential skin irritation and eye damage. The compound has a relatively high flash point (>100 C) but generates dust that may form explosive mixtures with air. APPLICATIONS: 5-chloroisoquinoline-8-carboxylic acid functions as a critical intermediate in synthesizing anticancer agents targeting specific protein kinases as documented in oncology research. Its chlorinated isoquinoline core enables the development of antimicrobial agents with activity against drug-resistant pathogens as reported in pharmaceutical chemistry literature. Additionally, 1935127-38-0 serves as a building block for fluorescent DNA intercalators used in genetic research, with several studies highlighting its role in creating sequence-specific DNA binding agents for molecular biology applications. The compound also contributes to the synthesis of agrochemical intermediates for developing fungicides with novel modes of action, as described in agricultural chemistry literature.
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