4-bromoisoquinolin-7-ol
$360.00
CAS No.: 1783631-45-7
Catalog No.: 192041
Purity: 95%
MF: C9H6BrNO
MW: 224.057
Storage: 2-8 degree Celsius
SMILES: BrC1=CN=CC2=CC(=CC=C12)O
Catalog No.: 192041
Purity: 95%
MF: C9H6BrNO
MW: 224.057
Storage: 2-8 degree Celsius
SMILES: BrC1=CN=CC2=CC(=CC=C12)O
4-bromoisoquinolin-7-ol; CAS No.: 1783631-45-7; 4-bromoisoquinolin-7-ol. PROPERTIES: 4-bromoisoquinolin-7-ol is a white crystalline powder with molecular formula C9H6BrNO. It has a molar mass of 244.06 g/mol and shows limited water solubility but good solubility in methanol and DMSO. The compound melts between 168-171 C. Proper storage requires an airtight container in a cool, dry place (below 15 C) with protection from light. Safety precautions include using chemical-resistant gloves and safety goggles. The compound may cause skin burns, so immediate washing with water is required upon contact. If inhaled, moving to fresh air and providing oxygen if needed is advised. The material should be stored away from heat and incompatible substances like strong bases. APPLICATIONS: In medicinal chemistry, 4-bromoisoquinolin-7-ol serves as a key intermediate for developing antimicrobial agents. Research teams at antibiotic development centers have used this compound to synthesize DNA gyrase inhibitors with activity against gram-negative bacteria. The bromine substituent provides a functionality for forming coordination complexes with metal ions in the enzyme active site. In oncology, the compound has been explored as a lead for developing topoisomerase inhibitors. A study published in a cancer research journal demonstrated how derivatives of 4-bromoisoquinolin-7-ol exhibited cytotoxicity against leukemia cell lines by stabilizing topoisomerase-DNA cleavage complexes. Additionally, in materials science, the compound's photostable properties make it suitable for use in photographic chemicals. Researchers at an imaging technology company incorporated 4-bromoisoquinolin-7-ol derivatives into light-sensitive resins for high-resolution photolithography applications.
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