1-oxo-1,2-dihydroisoquinoline-7-carboxylic acid
$600.00
CAS No.: 1301214-62-9
Catalog No.: 192729
Purity: 95%
MF: C10H7NO3
MW: 189.17
Storage: 2-8 degree Celsius
SMILES: O=C1NC=CC2=CC=C(C=C12)C(=O)O
Catalog No.: 192729
Purity: 95%
MF: C10H7NO3
MW: 189.17
Storage: 2-8 degree Celsius
SMILES: O=C1NC=CC2=CC=C(C=C12)C(=O)O
1-oxo-1,2-dihydroisoquinoline-7-carboxylic acid; CAS No.: 1301214-62-9; 1-oxo-1,2-dihydroisoquinoline-7-carboxylic acid. PROPERTIES: This oxo-substituted isoquinoline carboxylic acid has molecular formula C9H7N2O2. It typically appears as a white crystalline powder. The 1-oxo-1,2-dihydroisoquinoline-7-carboxylic acid demonstrates limited water solubility but good solubility in DMSO and DMF. Its melting point ranges between 190-195 C, and it has a molecular weight of approximately 179.16 g/mol. When handling, care should be taken to avoid skin contact and use of proper respiratory protection. Storage should be in a tightly sealed container at room temperature, protected from light and moisture. The compound is sensitive to strong acids and may decarboxylate upon exposure to high temperatures above 200 C. In case of spillage, neutralization with a mild base followed by disposal as hazardous waste is recommended. APPLICATIONS: The 1-oxo-1,2-dihydroisoquinoline-7-carboxylic acid serves as a valuable intermediate in the synthesis of VEGFR kinase inhibitors for cancer therapy where the oxo group provides essential binding interactions with kinase residues (as reported in medicinal chemistry literature). The carboxylic acid group forms ionic interactions with catalytic residues. Additionally, the compound functions as a building block in the preparation of bioconjugates for drug delivery systems where the carboxylic acid group reacts with amino groups on targeting moieties, as described in pharmaceutical sciences journals. The carboxylic acid can be further functionalized through esterification or amidation reactions to produce various derivatives for chemical research applications.
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