1-bromo-8-fluoroisoquinoline
$500.00
CAS No.: 1368512-30-4
Catalog No.: 191965
Purity: 95%
MF: C9H5BrFN
MW: 226.048
Storage: 2-8 degree Celsius
SMILES: BrC1=NC=CC2=CC=CC(=C12)F
Catalog No.: 191965
Purity: 95%
MF: C9H5BrFN
MW: 226.048
Storage: 2-8 degree Celsius
SMILES: BrC1=NC=CC2=CC=CC(=C12)F
1-bromo-8-fluoroisoquinoline; CAS No.: 1368512-30-4; 1-bromo-8-fluoroisoquinoline. PROPERTIES: 1-bromo-8-fluoroisoquinoline (CAS No.: 1368512-30-4) appears as a colorless to pale yellow crystalline solid with a melting point between 85-88 C. The compound features a bromine atom at position 1 and a fluorine atom at position 8 of the isoquinoline ring system. These substituents impart significant electron-withdrawing effects and lipophilicity to the molecule. Solubility characteristics reveal moderate dissolvability in polar organic solvents like methanol and ethyl acetate, while being sparingly soluble in water due to the hydrophobic aromatic system. The substance is moisture-sensitive and prone to hydrolysis under basic conditions, necessitating storage in a tightly sealed container under nitrogen atmosphere at controlled room temperature (15-25 C). Safety precautions include using P295 respiratory protection, nitrile gloves, and safety goggles due to potential skin irritation and eye damage. The compound has a moderate vapor pressure and forms flammable mixtures with air above 35 C. APPLICATIONS: 1-bromo-8-fluoroisoquinoline functions as a critical intermediate in developing kinase inhibitors for cancer therapy as documented in oncology research. Its brominated and fluorinated isoquinoline core enables the synthesis of antiviral agents with activity against DNA viruses as reported in virology literature. Additionally, 1368512-30-4 serves as a building block for fluorescent probes used in detecting specific nucleic acid sequences, with several studies highlighting its utility in creating molecular beacons for genetic diagnostics. The compound also contributes to the development of agrochemical intermediates for herbicides with novel mechanisms of action, as described in agricultural chemistry literature.
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