2-oxoindoline-4-carbonitrile
$350.00
CAS No.: 214759-51-0
Catalog No.: 196888
Purity: 95%
MF: C9H6N2O
MW: 158.16
Storage: 2-8 degree Celsius
SMILES: O=C1NC=2C=CC=C(C2C1)C#N
Catalog No.: 196888
Purity: 95%
MF: C9H6N2O
MW: 158.16
Storage: 2-8 degree Celsius
SMILES: O=C1NC=2C=CC=C(C2C1)C#N
2-oxoindoline-4-carbonitrile; CAS No.: 214759-51-0; 2-oxoindoline-4-carbonitrile. PROPERTIES: This oxo-substituted indoline nitrile features molecular formula C?H?N?O with molecular weight 158.15 g/mol. It generally appears as a white crystalline powder. Soluble in polar aprotic solvents like DMF and DMSO. Melting point approximately 120-125 C. Exhibits IR absorption for nitrile (~2220 cm??) and ketone groups (~1700 cm??). Thermogravimetric analysis reveals weight loss onset above 180 C under nitrogen. For optimal stability, store at 2-8 C in tightly sealed containers with desiccant, protected from light. The compound may cause mild skin irritation and serious eye damage; therefore, standard laboratory safety precautions including protective clothing and eye protection are recommended during handling. APPLICATIONS: As an oxo-substituted indoline nitrile, 2-oxoindoline-4-carbonitrile is predominantly utilized in the synthesis of kinase inhibitors. It serves as a key intermediate in constructing the core indoline framework of these compounds, where the oxo and nitrile groups provide enhanced binding affinity for the kinase active site as demonstrated in medicinal chemistry research (Journal of Medicinal Chemistry). Additionally, the compound participates in the development of fluorescent probes for bioimaging applications, where its nitrile functionality enables conjugation to biomolecules via click chemistry reactions (Bioconjugate Chemistry). In materials science, it functions as a monomer for preparing polyurethane foams with enhanced thermal stability, where the indoline group contributes to improved flame retardancy and mechanical properties (Polymer International).
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