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2-(2-hydroxyethoxy)isoindoline-1,3-dione; CAS No.: 32380-69-1; 2-(2-hydroxyethoxy)isoindoline-1,3-dione. PROPERTIES: This hydroxyethoxy-substituted isoindoline dione features molecular formula C??H?NO? with molecular weight 228.19 g/mol. It typically exists as a white crystalline powder. Soluble in polar protic solvents like methanol and water. Melting point approximately 140-145 C. Exhibits IR absorption for ester (~1750 cm??) and hydroxyl groups (~3300 cm??). Thermogravimetric analysis indicates decomposition above 180 C under nitrogen. For optimal stability, store at 2-8 C in tightly sealed containers with desiccant, protected from light. The compound may cause mild skin irritation and serious eye damage; therefore, standard laboratory safety precautions including protective clothing and eye protection are recommended during handling. APPLICATIONS: As a hydroxyethoxy-substituted isoindoline dione, 2-(2-hydroxyethoxy)isoindoline-1,3-dione is predominantly utilized in the synthesis of contrast agents for medical imaging. It serves as a key intermediate in constructing magnetic resonance imaging (MRI) contrast agents, where the hydroxyethoxy group provides valuable water solubility and the isoindoline dione structure enhances relaxivity properties as demonstrated in medicinal chemistry research (Journal of Medicinal Chemistry). Additionally, the compound participates in the development of fluorescent probes for bioimaging applications, where its dione functionality enables conjugation to biomolecules via oxime formation (Bioconjugate Chemistry). In materials science, it functions as a monomer for preparing polyurethane foams with enhanced thermal stability, where the isoindoline group contributes to improved flame retardancy and mechanical properties (Polymer International).