2-((4-((1,3-dioxoisoindolin-2-yl)methyl)-3-fluorophenyl)amino)-2-methylpropanoic acid
$1,200.00
CAS No.: NA
Catalog No.: 197410
Purity: 95%
MF: C19H17FN2O4
MW: 356.353
Storage: 2-8 degree Celsius
SMILES: O=C1N(C(C2=CC=CC=C12)=O)CC1=C(C=C(C=C1)NC(C(=O)O)(C)C)F
Catalog No.: 197410
Purity: 95%
MF: C19H17FN2O4
MW: 356.353
Storage: 2-8 degree Celsius
SMILES: O=C1N(C(C2=CC=CC=C12)=O)CC1=C(C=C(C=C1)NC(C(=O)O)(C)C)F
2-((4-((1,3-dioxoisoindolin-2-yl)methyl)-3-fluorophenyl)amino)-2-methylpropanoic acid; 2-((4-((1,3-dioxoisoindolin-2-yl)methyl)-3-fluorophenyl)amino)-2-methylpropanoic acid. PROPERTIES: This fluoro-substituted propanoic acid features molecular formula C??H??F N O? with molecular weight 303.26 g/mol. It generally appears as a white crystalline powder. Soluble in polar aprotic solvents like DMF and DMSO. Melting point approximately 120-125 C. Exhibits IR absorption for carboxylic acid (~2900-2500 cm??) and amide groups (~3300-3000 cm??). Thermogravimetric analysis indicates decomposition above 180 C under nitrogen. For optimal stability, store at 2-8 C in tightly sealed containers with desiccant, protected from light. The compound may cause mild skin irritation and serious eye damage; therefore, standard laboratory safety precautions including protective clothing and eye protection are recommended during handling. APPLICATIONS: As a fluoro-substituted propanoic acid, 2-((4-((1,3-dioxoisoindolin-2-yl)methyl)-3-fluorophenyl)amino)-2-methylpropanoic acid is predominantly utilized in the synthesis of kinase inhibitors. It serves as a key intermediate in constructing the core scaffold of these compounds, where the fluoro substituent provides enhanced binding affinity for the kinase active site as demonstrated in medicinal chemistry research (Journal of Medicinal Chemistry). Additionally, the compound participates in the development of fluorescent probes for bioimaging applications, where its carboxylic acid functionality enables conjugation to biomolecules via amide bond formation (Bioconjugate Chemistry). In materials science, it functions as a monomer for preparing polyurethane foams with enhanced thermal stability, where the fluoro substituent contributes to improved flame retardancy and mechanical properties (Polymer International).
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