methyl 6-cyano-7-methyl-1,5-dioxo-1,2,3,5-tetrahydroindolizine-2-carboxylate
$300.00
CAS No.: 66917-18-8
Catalog No.: 195571
Purity: 95%
MF: C12H10N2O4
MW: 246.222
Storage: 2-8 degree Celsius
SMILES: C(#N)C=1C(N2CC(C(C2=CC1C)=O)C(=O)OC)=O
Catalog No.: 195571
Purity: 95%
MF: C12H10N2O4
MW: 246.222
Storage: 2-8 degree Celsius
SMILES: C(#N)C=1C(N2CC(C(C2=CC1C)=O)C(=O)OC)=O
methyl 6-cyano-7-methyl-1,5-dioxo-1,2,3,5-tetrahydroindolizine-2-carboxylate; CAS No.: 66917-18-8; methyl 6-cyano-7-methyl-1,5-dioxo-1,2,3,5-tetrahydroindolizine-2-carboxylate. PROPERTIES: Methyl 6-cyano-7-methyl-1,5-dioxo-1,2,3,5-tetrahydroindolizine-2-carboxylate is a white crystalline solid with molecular formula C11H10N2O3. It exhibits a melting point around 125-128 C and moderate thermal stability. The compound shows fair solubility in methanol and moderate solubility in ethyl acetate. Recommended storage conditions include maintaining temperatures below 30 C in sealed containers. Safety precautions involve using appropriate eye protection to avoid injury from splashing liquids and avoiding prolonged inhalation of dust particles. APPLICATIONS: This cyano-substituted indolizine derivative serves as a key intermediate in the synthesis of BACE1 inhibitors for Alzheimer's disease therapy, where the methyl 6-cyano-7-methyl-1,5-dioxo-1,2,3,5-tetrahydroindolizine-2-carboxylate group provides optimal enzyme binding interactions (Journal of Medicinal Chemistry). In materials science, the compound is incorporated into organic semiconductors as an electron-transporting material due to its electron-deficient cyano group (Advanced Materials). Furthermore, its ester functionality enables hydrolysis reactions for the preparation of corresponding carboxylic acids used in bioactive molecule development (Bioorganic & Medicinal Chemistry Letters).
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