ethyl indolizine-7-carboxylate
$365.00
CAS No.: 66182-02-3
Catalog No.: 192700
Purity: 95%
MF: C11H11NO2
MW: 189.214
Storage: 2-8 degree Celsius
SMILES: C=1C=CN2C=CC(=CC12)C(=O)OCC
Catalog No.: 192700
Purity: 95%
MF: C11H11NO2
MW: 189.214
Storage: 2-8 degree Celsius
SMILES: C=1C=CN2C=CC(=CC12)C(=O)OCC
ethyl indolizine-7-carboxylate; CAS No.: 66182-02-3; ethyl indolizine-7-carboxylate. PROPERTIES: This indolizine ester has molecular formula C10H10N2O2. It generally appears as a pale yellow oil. The ethyl indolizine-7-carboxylate demonstrates moderate solubility in common organic solvents like methanol and ethyl acetate but limited water solubility. Its boiling point ranges between 185-190 C at 760 mmHg, and it has a molecular weight of approximately 190.19 g/mol. When handling, care should be taken to avoid skin contact and use of proper respiratory protection. Storage should be in a tightly sealed container at room temperature, protected from light and moisture. The compound is sensitive to strong acids and may hydrolyze to the corresponding carboxylic acid upon exposure to aqueous conditions. In case of spillage, absorb with inert material and dispose of in accordance with local regulations. APPLICATIONS: The ethyl indolizine-7-carboxylate functions as a valuable intermediate in the synthesis of VEGFR kinase inhibitors for cancer therapy where the ester group provides essential hydrogen bonding interactions with kinase domains (as detailed in medicinal chemistry literature). The indolizine ring provides planar aromatic interactions important for binding affinity. Additionally, the compound serves as a building block in the preparation of liquid crystal materials with specific dielectric properties, useful in display technologies with response times below 20 milliseconds as described in materials chemistry journals. The ester group can be further functionalized through hydrolysis or transesterification reactions to produce various derivatives for chemical research applications.
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