7-methyl-1,5-dioxo-1,2,3,5-tetrahydroindolizine-6-carbonitrile
$300.00
CAS No.: 58610-63-2
Catalog No.: 195572
Purity: 95%
MF: C10H8N2O2
MW: 188.186
Storage: 2-8 degree Celsius
SMILES: CC1=C(C(N2CCC(C2=C1)=O)=O)C#N
Catalog No.: 195572
Purity: 95%
MF: C10H8N2O2
MW: 188.186
Storage: 2-8 degree Celsius
SMILES: CC1=C(C(N2CCC(C2=C1)=O)=O)C#N
7-methyl-1,5-dioxo-1,2,3,5-tetrahydroindolizine-6-carbonitrile; CAS No.: 58610-63-2; 7-methyl-1,5-dioxo-1,2,3,5-tetrahydroindolizine-6-carbonitrile. PROPERTIES: 7-methyl-1,5-dioxo-1,2,3,5-tetrahydroindolizine-6-carbonitrile is a white crystalline powder with molecular formula C9H8N2O2. It exhibits a melting point around 135-138 C and demonstrates good thermal stability. The compound shows fair solubility in methanol and moderate solubility in ethyl acetate. Recommended storage conditions include maintaining temperatures below 25 C in sealed containers. Safety precautions involve using appropriate eye protection to avoid injury from splashing liquids and avoiding prolonged inhalation of dust particles. APPLICATIONS: This methylated indolizine nitrile serves as a valuable intermediate in the development of cholesterol absorption inhibitors, where the 7-methyl-1,5-dioxo-1,2,3,5-tetrahydroindolizine-6-carbonitrile group contributes to NPC1L1 protein binding (Journal of Medicinal Chemistry). In agrochemical research, the compound is used as a lead structure for developing herbicides targeting specific plant enzyme systems (Pest Management Science). Furthermore, its nitrile functionality enables hydrolysis reactions for the preparation of corresponding carboxylic acids used in medicinal chemistry library development (Bioorganic & Medicinal Chemistry Letters).
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