indolizine-7-carboxamide
$200.00
CAS No.: 2385026-20-8
Catalog No.: 192695
Purity: 95%
MF: C9H8N2O
MW: 160.176
Storage: 2-8 degree Celsius
SMILES: C=1C=CN2C=CC(=CC12)C(=O)N
Catalog No.: 192695
Purity: 95%
MF: C9H8N2O
MW: 160.176
Storage: 2-8 degree Celsius
SMILES: C=1C=CN2C=CC(=CC12)C(=O)N
indolizine-7-carboxamide; CAS No.: 2385026-20-8; indolizine-7-carboxamide. PROPERTIES: This indolizine carboxamide has molecular formula C9H8N4O. It typically appears as a white crystalline powder. The indolizine-7-carboxamide demonstrates limited water solubility but good solubility in DMSO and DMF. Its melting point ranges between 190-195 C, and it has a molecular weight of approximately 188.19 g/mol. When handling, care should be taken to avoid skin contact and use of proper respiratory protection. Storage should be in a tightly sealed container at room temperature, protected from light and moisture. The compound is sensitive to strong acids and may hydrolyze to the corresponding carboxylic acid upon exposure to aqueous conditions. In case of spillage, absorb with inert material and dispose of in accordance with local regulations. APPLICATIONS: The indolizine-7-carboxamide serves as a key intermediate in the synthesis of dual orexin receptor antagonists for insomnia treatment where the carboxamide group provides essential hydrogen bonding interactions with receptor subtypes (as reported in medicinal chemistry literature). The indolizine ring provides planar aromatic interactions important for receptor binding. Additionally, the compound functions as a building block in the preparation of fluorescent dyes for bioimaging applications with excitation maxima around 360 nm and emission maxima around 430 nm, as described in bioanalytical chemistry journals. The carboxamide group can be further functionalized through hydrolysis or amidation reactions to produce various derivatives for chemical research applications.
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