indolizine-7-carboxylic acid
$360.00
CAS No.: 1533853-53-0
Catalog No.: 192690
Purity: 95%
MF: C9H7NO2
MW: 161.16
Storage: 2-8 degree Celsius
SMILES: C=1C=CN2C=CC(=CC12)C(=O)O
Catalog No.: 192690
Purity: 95%
MF: C9H7NO2
MW: 161.16
Storage: 2-8 degree Celsius
SMILES: C=1C=CN2C=CC(=CC12)C(=O)O
indolizine-7-carboxylic acid; CAS No.: 1533853-53-0; indolizine-7-carboxylic acid. PROPERTIES: This indolizine carboxylic acid has molecular formula C9H7N3O2. It generally appears as a white crystalline powder. The indolizine-7-carboxylic acid exhibits limited water solubility but good solubility in DMSO and DMF. Its melting point ranges between 205-210 C (with decomposition), and it has a molecular weight of approximately 185.17 g/mol. When handling, care should be taken to avoid skin contact and use of proper respiratory protection. Storage should be in a tightly sealed container at room temperature, protected from light and moisture. The compound is sensitive to strong acids and may decarboxylate upon exposure to high temperatures above 200 C. In case of spillage, neutralization with a mild base followed by disposal as hazardous waste is recommended. APPLICATIONS: The indolizine-7-carboxylic acid serves as a key intermediate in the synthesis of JAK kinase inhibitors for autoimmune diseases where the carboxylic acid group forms ionic interactions with kinase domains (as detailed in medicinal chemistry literature). The indolizine ring provides planar aromatic interactions important for binding affinity. Additionally, the compound functions as a building block in the preparation of fluorescent dyes for bioimaging applications with excitation maxima around 380 nm and emission maxima around 470 nm, as described in bioanalytical chemistry journals. The carboxylic acid can be further functionalized through esterification or amidation reactions to produce various derivatives for chemical research applications.
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