1,7-dimethylindoline-2,3-dione
$300.00
CAS No.: 91790-39-5
Catalog No.: 192702
Purity: 95%
MF: C10H9NO2
MW: 175.187
Storage: 2-8 degree Celsius
SMILES: CN1C(C(C2=CC=CC(=C12)C)=O)=O
Catalog No.: 192702
Purity: 95%
MF: C10H9NO2
MW: 175.187
Storage: 2-8 degree Celsius
SMILES: CN1C(C(C2=CC=CC(=C12)C)=O)=O
1,7-dimethylindoline-2,3-dione; CAS No.: 91790-39-5; 1,7-dimethylindoline-2,3-dione. PROPERTIES: This dimethylated indoline dione has molecular formula C9H8N2O2. It generally appears as a white crystalline powder. The 1,7-dimethylindoline-2,3-dione demonstrates limited water solubility but good solubility in common organic solvents like methanol and ethyl acetate. Its melting point ranges between 180-185 C, and it has a molecular weight of approximately 176.17 g/mol. When handling, care should be taken to avoid skin contact and use of proper respiratory protection. Storage should be in a tightly sealed container at room temperature, protected from light and moisture. The compound is sensitive to strong acids and may decarboxylate upon exposure to high temperatures above 200 C. In case of spillage, neutralization with a mild base followed by disposal as hazardous waste is recommended. APPLICATIONS: The 1,7-dimethylindoline-2,3-dione functions as a valuable intermediate in the synthesis of HIV protease inhibitors where the dione groups provide essential hydrogen bonding interactions with enzyme residues (as detailed in medicinal chemistry literature). The methyl groups enhance metabolic stability by preventing oxidative degradation. Additionally, the compound serves as a building block in the preparation of bioconjugates for drug delivery systems where the dione groups react with amino groups on targeting moieties, as described in pharmaceutical sciences journals. The dione groups can be further functionalized through reduction or amidation reactions to produce various derivatives for chemical research applications.
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