2-(1-(benzyloxy)-2-methylpropan-2-yl)-6-fluoro-5-nitro-1H-indole
$400.00
CAS No.: 1638771-94-4
Catalog No.: 195550
Purity: 95%
MF: C19H19FN2O3
MW: 342.37
Storage: 2-8 degree Celsius
SMILES: C(C1=CC=CC=C1)OCC(C)(C)C=1NC2=CC(=C(C=C2C1)[N+](=O)[O-])F
Catalog No.: 195550
Purity: 95%
MF: C19H19FN2O3
MW: 342.37
Storage: 2-8 degree Celsius
SMILES: C(C1=CC=CC=C1)OCC(C)(C)C=1NC2=CC(=C(C=C2C1)[N+](=O)[O-])F
2-(1-(benzyloxy)-2-methylpropan-2-yl)-6-fluoro-5-nitro-1H-indole; CAS No.: 1638771-94-4; 2-(1-(benzyloxy)-2-methylpropan-2-yl)-6-fluoro-5-nitro-1H-indole. PROPERTIES: 2-(1-(benzyloxy)-2-methylpropan-2-yl)-6-fluoro-5-nitro-1H-indole is a yellowish solid with molecular formula C16H16FN3O4. It demonstrates a melting point around 115-118 C and moderate thermal stability. The compound shows fair solubility in methylene chloride and moderate solubility in ethyl acetate. Recommended storage requires keeping it in tightly sealed containers at 2-8 C to prevent degradation. Safety precautions include using explosion-proof equipment when handling due to potential flammability and employing proper engineering controls to minimize exposure to nitro group-containing vapors. APPLICATIONS: This benzyloxy-protected indole derivative serves as a valuable intermediate in the synthesis of tyrosine kinase inhibitors for cancer therapy, where the 2-(1-(benzyloxy)-2-methylpropan-2-yl)-6-fluoro-5-nitro-1H-indole group provides steric and electronic features conducive to target binding (Journal of Medicinal Chemistry). In chemical biology, the compound is used as a scaffold for developing photoaffinity labels targeting protein kinases involved in signal transduction (ACS Chemical Biology). Furthermore, its nitro group enables reduction reactions for the preparation of corresponding anilines used in bioactive molecule development (Bioorganic & Medicinal Chemistry Letters).
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