1H-indole-7-carboxylic acid
$200.00
CAS No.: 1670-83-3
Catalog No.: 196201
Purity: 95%
MF: C9H7NO2
MW: 161.16
Storage: 2-8 degree Celsius
SMILES: N1C=CC2=CC=CC(=C12)C(=O)O
Catalog No.: 196201
Purity: 95%
MF: C9H7NO2
MW: 161.16
Storage: 2-8 degree Celsius
SMILES: N1C=CC2=CC=CC(=C12)C(=O)O
1H-indole-7-carboxylic acid; CAS No.: 1670-83-3; 1H-indole-7-carboxylic acid. PROPERTIES: This compound features a 1H-indole-7-carboxylic acid structure, combining a carboxylic acid group and an indole ring system. It typically appears as a white to off-white crystalline solid with a molecular weight of approximately 179.2 g/mol (C10H8N2O2). The melting point ranges between 200-205 C, and it exhibits moderate solubility in common organic solvents like ethanol, methanol, and DMSO while being sparingly soluble in water. Proper storage requires a tightly sealed container in a cool, dry place. Safety considerations include wearing appropriate PPE. It is classified as a skin and eye irritant (GHS07) with the hazard statement H315-H319. APPLICATIONS: 1H-Indole-7-carboxylic acid serves as a valuable intermediate in pharmaceutical and chemical synthesis. Its 1H-indole-7-carboxylic acid structure enables participation in various reactions, including esterification, amide bond formation, and nucleophilic substitution at the indole ring. In medicinal chemistry, it is used to develop bioactive molecules targeting the central nervous system and inflammatory pathways. The carboxylic acid group can be converted to bioisosteric replacements like tetrazole or phosphonic acid. This compound also functions as a building block in the synthesis of fluorescent probes and bioconjugation reagents. Academic studies employ it as a model compound in Medicinal Chemistry journals, focusing on optimizing the 1H-indole-7-carboxylic acid scaffold for improved biological activity and pharmacokinetic properties.
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