2-methyl-1H-indole-3-carbaldehyde
$375.00
CAS No.: 5416-80-8
Catalog No.: 196203
Purity: 95%
MF: C10H9NO
MW: 159.188
Storage: 2-8 degree Celsius
SMILES: CC=1NC2=CC=CC=C2C1C=O
Catalog No.: 196203
Purity: 95%
MF: C10H9NO
MW: 159.188
Storage: 2-8 degree Celsius
SMILES: CC=1NC2=CC=CC=C2C1C=O
2-methyl-1H-indole-3-carbaldehyde; CAS No.: 5416-80-8; 2-methyl-1H-indole-3-carbaldehyde. PROPERTIES: This compound presents a 2-methyl-1H-indole-3-carbaldehyde structure, combining a methyl group, an indole ring system, and an aldehyde group. It typically appears as a white to off-white crystalline solid with a molecular weight of approximately 179.2 g/mol (C11H9NO). The melting point ranges between 100-105 C, and it exhibits moderate solubility in common organic solvents like ethyl acetate, dichloromethane, and tetrahydrofuran while being sparingly soluble in water. Proper storage requires a tightly sealed container in a cool, dry place. Safety considerations include wearing appropriate PPE. It is classified as a skin and eye irritant (GHS07) with the hazard statement H315-H319. APPLICATIONS: 2-Methyl-1H-indole-3-carbaldehyde serves as a versatile intermediate in pharmaceutical and chemical synthesis. Its 2-methyl-1H-indole-3-carbaldehyde structure enables diverse reactivity patterns, including nucleophilic addition at the aldehyde carbonyl and electrophilic substitution at the indole ring. In medicinal chemistry, it is used to develop bioactive molecules targeting kinases, G protein-coupled receptors, and proteases. The aldehyde group can be readily modified through reductive amination or cyanosilylation. This compound also functions as a building block in the synthesis of fluorescent dyes and bioconjugation reagents. Academic studies employ it as a model system in Organic Chemistry journals, focusing on the development of novel indole derivatives based on the 2-methyl-1H-indole-3-carbaldehyde scaffold.
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