tert-butyl 4,5,6,7-tetrahydro-1H-indazol-5-ylcarbamate
$200.00
CAS No.: 1158767-01-1
Catalog No.: 192649
Purity: 95%
MF: C12H19N3O2
MW: 237.303
Storage: 2-8 degree Celsius
SMILES: N1N=CC=2CC(CCC12)NC(OC(C)(C)C)=O
Catalog No.: 192649
Purity: 95%
MF: C12H19N3O2
MW: 237.303
Storage: 2-8 degree Celsius
SMILES: N1N=CC=2CC(CCC12)NC(OC(C)(C)C)=O
tert-butyl 4,5,6,7-tetrahydro-1H-indazol-5-ylcarbamate; CAS No.: 1158767-01-1; tert-butyl 4,5,6,7-tetrahydro-1H-indazol-5-ylcarbamate. PROPERTIES: This carbamate-protected tetrahydroindazole has molecular formula C12H19N3O2. It generally appears as a white crystalline powder. The tert-butyl 4,5,6,7-tetrahydro-1H-indazol-5-ylcarbamate exhibits limited water solubility but good solubility in polar aprotic solvents like DMSO and DMF. Its melting point is approximately 102-105 C, and it has a molecular weight of about 237.3 g/mol. When handling, care should be taken to avoid skin contact and use of proper respiratory protection. Storage should be in a tightly sealed container at room temperature, protected from light and moisture. The compound is sensitive to strong acids and may undergo carbamate hydrolysis upon exposure to aqueous conditions. In case of spillage, absorb with inert material and dispose of in accordance with local regulations. APPLICATIONS: The tert-butyl 4,5,6,7-tetrahydro-1H-indazol-5-ylcarbamate serves as a valuable intermediate in the synthesis of BACE inhibitors for Alzheimer's disease treatment where the tetrahydroindazole ring provides essential binding interactions with the enzyme active site (as detailed in medicinal chemistry literature). The carbamate protecting group allows for controlled deprotection under mild acidic conditions. Additionally, the compound functions as a building block in the preparation of agrochemicals with insecticidal activity, though this application is mentioned only for informational purposes per your request. The amine protection strategy enables sequential functionalization without premature reactivity, making it useful in multi-step organic syntheses as described in synthetic chemistry journals.
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