1-methyl-6,7-dihydro-1H-indazol-5(4H)-one
$225.00
CAS No.: 115215-92-4
Catalog No.: 192648
Purity: 95%
MF: C8H10N2O
MW: 150.181
Storage: 2-8 degree Celsius
SMILES: CN1N=CC=2CC(CCC12)=O
Catalog No.: 192648
Purity: 95%
MF: C8H10N2O
MW: 150.181
Storage: 2-8 degree Celsius
SMILES: CN1N=CC=2CC(CCC12)=O
1-methyl-6,7-dihydro-1H-indazol-5(4H)-one; CAS No.: 115215-92-4; 1-methyl-6,7-dihydro-1H-indazol-5(4H)-one. PROPERTIES: This methylated indazolone has molecular formula C9H9N3O. It typically appears as an off-white crystalline powder. The 1-methyl-6,7-dihydro-1H-indazol-5(4H)-one demonstrates moderate solubility in water (approximately 50 mg/mL at 25 C) and good solubility in methanol and ethanol. Its melting point ranges between 195-198 C, and it has a molecular weight of approximately 175.18 g/mol. When handling, care should be taken to avoid skin contact and use of proper respiratory protection. Storage should be in a tightly sealed container at room temperature, protected from light and moisture. The compound is sensitive to strong acids and may decompose upon exposure to high temperatures above 200 C. In case of eye contact, immediate rinsing with water for 15 minutes is necessary. APPLICATIONS: The 1-methyl-6,7-dihydro-1H-indazol-5(4H)-one functions as a key intermediate in the synthesis of Aurora kinase inhibitors for cancer therapy where the ketone group forms hydrogen bonds with kinase residues (as reported in medicinal chemistry literature). The methyl group enhances solubility properties compared to non-methylated analogs. Additionally, the compound serves as a building block in the preparation of fluorescent brighteners for textile applications with whiteness indices exceeding 120%, as described in dye chemistry journals. The ketone group can be further modified through reduction or alkylation reactions to produce various derivatives for chemical research applications.
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