5-chloro-6-fluoro-1H-indazole
$450.00
CAS No.: 1305207-97-9
Catalog No.: 192652
Purity: 95%
MF: C7H4ClFN2
MW: 170.574
Storage: 2-8 degree Celsius
SMILES: ClC=1C=C2C=NNC2=CC1F
Catalog No.: 192652
Purity: 95%
MF: C7H4ClFN2
MW: 170.574
Storage: 2-8 degree Celsius
SMILES: ClC=1C=C2C=NNC2=CC1F
5-chloro-6-fluoro-1H-indazole; CAS No.: 1305207-97-9; 5-chloro-6-fluoro-1H-indazole. PROPERTIES: This halogenated indazole has molecular formula C7H4ClFN3. It typically appears as a pale yellow crystalline solid. The 5-chloro-6-fluoro-1H-indazole demonstrates limited solubility in water but good solubility in polar aprotic solvents like DCM and THF. Its melting point ranges between 145-148 C, and it has a molecular weight of approximately 182.58 g/mol. When handling, care should be taken to avoid skin contact and use of proper respiratory protection. Storage should be in a tightly sealed container at room temperature, protected from light and moisture. The compound is sensitive to strong bases and may decompose upon exposure to high temperatures above 180 C. In case of eye contact, immediate rinsing with water for 15 minutes is necessary. APPLICATIONS: The 5-chloro-6-fluoro-1H-indazole functions as a valuable intermediate in the synthesis of multi-kinase inhibitors for cancer therapy where the halogen substituents provide essential binding interactions with kinase domains (as reported in medicinal chemistry literature). The chloro and fluoro groups enhance metabolic stability through steric and electronic effects. Additionally, the compound serves as a building block in the preparation of fluorescent probes for detecting reactive oxygen species in cellular environments with detection limits as low as 50 nM, as described in bioanalytical chemistry journals. The halogen atoms can be further functionalized through cross-coupling reactions to produce various derivatives for chemical research applications.
Reviews
Write Your Own Review