3-bromo-1H-indazole-4-carboxylic acid
$225.00
CAS No.: 1363382-97-1
Catalog No.: 192653
Purity: 95%
MF: C8H5BrN2O2
MW: 241.044
Storage: 2-8 degree Celsius
SMILES: BrC1=NNC=2C=CC=C(C12)C(=O)O
Catalog No.: 192653
Purity: 95%
MF: C8H5BrN2O2
MW: 241.044
Storage: 2-8 degree Celsius
SMILES: BrC1=NNC=2C=CC=C(C12)C(=O)O
3-bromo-1H-indazole-4-carboxylic acid; CAS No.: 1363382-97-1; 3-bromo-1H-indazole-4-carboxylic acid. PROPERTIES: This brominated indazole carboxylic acid has molecular formula C8H5BrN2O2. It generally appears as a white to slightly yellow crystalline powder. The 3-bromo-1H-indazole-4-carboxylic acid exhibits limited water solubility but good solubility in DMSO and DMF. Its melting point ranges between 210-215 C (with decomposition), and it has a molecular weight of approximately 245.04 g/mol. When handling, care should be taken to avoid skin contact and use of proper respiratory protection. Storage should be in a tightly sealed container at room temperature, protected from light and moisture. The compound is sensitive to strong acids and may decarboxylate upon exposure to high temperatures above 200 C. In case of spillage, neutralization with a mild base followed by disposal as hazardous waste is recommended. APPLICATIONS: The 3-bromo-1H-indazole-4-carboxylic acid serves as a key intermediate in the synthesis of HCV NS5B polymerase inhibitors where the carboxylic acid group forms ionic interactions with viral enzyme residues (as detailed in antiviral research literature). The bromine atom provides additional binding affinity through halogen bonding. Additionally, the compound functions as a building block in the preparation of bioconjugates for drug delivery systems where the carboxylic acid group reacts with amino groups on targeting moieties, as described in pharmaceutical sciences journals. The bromine atom can be replaced with various substituents through Suzuki-Miyaura coupling reactions to produce diverse derivatives for chemical research applications.
Reviews
Write Your Own Review