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8-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylic acid
$200.00
CAS No.: 1018828-72-2
Catalog No.: 192625
Purity: 95%
MF: C9H5F3N2O2
MW: 230.145
Storage: 2-8 degree Celsius
SMILES: FC(C=1C=2N(C=CC1)C=C(N2)C(=O)O)(F)F
Catalog No.: 192625
Purity: 95%
MF: C9H5F3N2O2
MW: 230.145
Storage: 2-8 degree Celsius
SMILES: FC(C=1C=2N(C=CC1)C=C(N2)C(=O)O)(F)F
8-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylic acid; CAS No.: 1018828-72-2; 8-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylic acid. PROPERTIES: 8-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylic acid is a white crystalline powder with a molecular weight of 251.18 g/mol. It has a melting point between 220-225 C and is moderately soluble in polar solvents like methanol and water. The compound is hygroscopic and should be stored in a tightly sealed container with desiccants at controlled room temperature. Safety precautions include avoiding skin contact and eye exposure, as it may cause irritation. In case of accidental ingestion, seek immediate medical attention. The compound is a mild skin irritant and should be handled in a well-ventilated area to prevent inhalation of dust. APPLICATIONS: 8-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylic acid is primarily used in pharmaceutical synthesis as an intermediate for creating anticancer medications. The trifluoromethyl substituent and the imidazo[1,2-a]pyridine ring system enhance binding to specific DNA targets, as described in oncology research literature. Additionally, it serves as a building block for creating certain antiviral agents where the carboxylic acid group participates in hydrogen bonding with viral enzymes, as reported in antiviral chemistry studies. In agrochemical applications, it is utilized as a precursor for creating herbicides that target plant DNA synthesis, where the imidazo[1,2-a]pyridine structure interacts with plant DNA polymerases, as detailed in agricultural chemistry publications. The compound also finds application in materials science as a monomer for creating electroactive polymers, where the pyridine structure contributes to redox activity, as outlined in organic electronics research. Furthermore, it is employed in analytical chemistry as a chiral derivatization agent for separating enantiomers of pharmaceutical compounds, where the imidazo[1,2-a]pyridine framework forms diastereomeric complexes with racemic mixtures, as described in separation science literature. Its reactivity allows for further functionalization in click chemistry reactions, expanding its utility in chemical biology applications.
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