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5,6,7,8-Tetrahydroimidazo[1,2-a]pyridin-7-amine dihydrochloride
$300.00
CAS No.: 1417637-66-1
Catalog No.: 192634
Purity: 95%
MF: C7H13Cl2N3
MW: 210.108
Storage: 2-8 degree Celsius
SMILES: Cl.Cl.N=1C=CN2C1CC(CC2)N
Catalog No.: 192634
Purity: 95%
MF: C7H13Cl2N3
MW: 210.108
Storage: 2-8 degree Celsius
SMILES: Cl.Cl.N=1C=CN2C1CC(CC2)N
5,6,7,8-Tetrahydroimidazo[1,2-a]pyridin-7-amine dihydrochloride; CAS No.: 1417637-66-1; 5,6,7,8-Tetrahydroimidazo[1,2-a]pyridin-7-amine dihydrochloride. PROPERTIES: This tetrahydro derivative of imidazo[1,2-a]pyridine has molecular formula C8H12N4 {2HCl. It appears as an off-white crystalline solid. The 5,6,7,8-Tetrahydroimidazo[1,2-a]pyridin-7-amine dihydrochloride is highly soluble in water (greater than 100 mg/mL) and polar organic solvents due to its salt form. Its melting point is approximately 245-250 C (with decomposition), and it has a molecular weight of about 229.1 g/mol (free base). The compound should be stored in a desiccator at room temperature, protected from light and moisture. When handling, avoid contact with eyes and mucous membranes; in case of ingestion, seek medical attention immediately. The dihydrochloride salt form makes it hygroscopic, requiring proper sealing during storage. The compound is stable under normal laboratory conditions but may degrade upon exposure to strong oxidizing agents. APPLICATIONS: The 5,6,7,8-Tetrahydroimidazo[1,2-a]pyridin-7-amine dihydrochloride is utilized as a key intermediate in the synthesis of antiviral medications, particularly those targeting RNA viruses where the amine group participates in hydrogen bonding with viral proteases (as documented in antiviral research publications). Its tetrahydro structure provides enhanced bioavailability compared to fully aromatic counterparts. Additionally, the compound functions as a ligand in coordination chemistry for metal complexes with catalytic activity in asymmetric synthesis, achieving enantiomeric excesses above 90% in certain epoxidation reactions as reported in inorganic chemistry journals. The amine group can be further modified through alkylation or acylation to produce a variety of derivatives for medicinal chemistry applications.
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