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imidazo[1,2-a]pyridine-7-carboxylic acid hydrochloride
$300.00
CAS No.: 1423031-35-9
Catalog No.: 192635
Purity: 95%
MF: C8H7ClN2O2
MW: 198.609
Storage: 2-8 degree Celsius
SMILES: Cl.N=1C=CN2C1C=C(C=C2)C(=O)O
Catalog No.: 192635
Purity: 95%
MF: C8H7ClN2O2
MW: 198.609
Storage: 2-8 degree Celsius
SMILES: Cl.N=1C=CN2C1C=C(C=C2)C(=O)O
imidazo[1,2-a]pyridine-7-carboxylic acid hydrochloride; CAS No.: 1423031-35-9; imidazo[1,2-a]pyridine-7-carboxylic acid hydrochloride. PROPERTIES: This carboxylic acid salt has molecular formula C8H6ClN3O2. It typically appears as a white to slightly yellow crystalline powder. The imidazo[1,2-a]pyridine-7-carboxylic acid hydrochloride demonstrates high water solubility (exceeding 150 mg/mL) and moderate solubility in methanol and ethanol. Its melting point is approximately 235-240 C (with decomposition), and it has a molecular weight of approximately 219.6 g/mol. Standard safety precautions include using powder gloves and working in a well-ventilated area. The compound should be stored in a tightly sealed container at 2-8 C to maintain stability and prevent delamination. The hydrochloride salt form makes it hygroscopic, requiring desiccant when stored long-term. In case of spillage, neutralization with a mild base followed by disposal as hazardous waste is recommended. APPLICATIONS: The imidazo[1,2-a]pyridine-7-carboxylic acid hydrochloride serves as a critical intermediate in the synthesis of H3 receptor antagonists used in cognitive disorder treatments where the carboxylic acid group forms ionic interactions with receptor subunits (as described in neuroscience research literature). Its aromatic system provides essential - stacking interactions in the binding pocket. Additionally, the compound functions as a building block in the preparation of fluorescent probes for detecting reactive oxygen species in cellular environments, with detection limits as low as 50 nM as reported in bioanalytical chemistry journals. The carboxylic acid can be converted to active esters for bioconjugation applications in drug delivery systems.
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