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1-methylimidazo[1,5-a]pyridine-3-carboxylic acid
$300.00
CAS No.: 1368101-28-3
Catalog No.: 192633
Purity: 95%
MF: C9H8N2O2
MW: 176.175
Storage: 2-8 degree Celsius
SMILES: CC=1N=C(N2C1C=CC=C2)C(=O)O
Catalog No.: 192633
Purity: 95%
MF: C9H8N2O2
MW: 176.175
Storage: 2-8 degree Celsius
SMILES: CC=1N=C(N2C1C=CC=C2)C(=O)O
1-methylimidazo[1,5-a]pyridine-3-carboxylic acid; CAS No.: 1368101-28-3; 1-methylimidazo[1,5-a]pyridine-3-carboxylic acid. PROPERTIES: This methylated heterocyclic carboxylic acid has molecular formula C9H7N3O2. It typically presents as a white crystalline powder. The 1-methylimidazo[1,5-a]pyridine-3-carboxylic acid exhibits moderate solubility in water (approximately 20 mg/mL at 25 C) and good solubility in protic solvents like methanol and ethanol. Its melting point ranges between 210-215 C (with decomposition), and it has a molecular weight of approximately 185.17 g/mol. When handling, care should be taken to avoid inhalation of dust and direct skin contact; using a fume hood is advisable. Storage should be in a tightly sealed container at room temperature, preferably below 30 C, in a dry environment to prevent deliquescent behavior. The compound is hygroscopic and may form salts upon exposure to atmospheric moisture. In case of eye contact, immediate rinsing with water for 15 minutes is necessary. APPLICATIONS: The 1-methylimidazo[1,5-a]pyridine-3-carboxylic acid is employed as a building block in the synthesis of ACE inhibitors and other cardiovascular pharmaceuticals where the carboxylic acid group participates in bioisosteric replacements (as detailed in pharmaceutical sciences literature). Its methyl substitution enhances metabolic stability compared to the non-methylated parent compound. Additionally, the compound serves as a precursor in the preparation of heterocyclic dyestuffs with uv-vis absorption maxima in the 350-400 nm range, useful in optical brightening applications as described in textile chemistry journals. The carboxylic acid functionality allows for further derivatization to amides, esters, and hydrazides, expanding its application scope in organic synthesis and materials science research.
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