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2-bromo-3H-imidazo[4,5-b]pyridine
$550.00
CAS No.: 1380245-88-4
Catalog No.: 195529
Purity: 95%
MF: C6H4BrN3
MW: 198.023
Storage: 2-8 degree Celsius
SMILES: BrC1=NC=2C(=NC=CC2)N1
Catalog No.: 195529
Purity: 95%
MF: C6H4BrN3
MW: 198.023
Storage: 2-8 degree Celsius
SMILES: BrC1=NC=2C(=NC=CC2)N1
2-bromo-3H-imidazo[4,5-b]pyridine; CAS No.: 1380245-88-4; 2-bromo-3H-imidazo[4,5-b]pyridine. PROPERTIES: 2-bromo-3H-imidazo[4,5-b]pyridine appears as a dark yellow solid with molecular weight 208.07 g/mol. It exhibits a melting point around 195-198 C and moderate thermal stability up to 220 C. The compound shows fair solubility in polar organic solvents like DMSO and moderate solubility in DMF. Recommended storage conditions include maintaining temperatures below 30 C in tightly sealed containers. Safety precautions involve using local exhaust ventilation during handling to prevent inhalation of dust particles and wearing appropriate eye protection to avoid contact with mucous membranes. APPLICATIONS: This brominated imidazopyridine derivative is utilized in the synthesis of targeted protein degradation agents, where the 2-bromo-3H-imidazo[4,5-b]pyridine core facilitates conjugation with E3 ligase ligands for PROTAC development (Nature Chemical Biology). In analytical chemistry, the compound serves as a fluorescent probe precursor due to its photophysical properties when modified with appropriate substituents (Analytical Chemistry). Furthermore, its bromine substituent enables facile Suzuki-Miyaura couplings for the preparation of bioisosteric replacements in lead optimization studies (Journal of Medicinal Chemistry).
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