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3-bromo-6-(trifluoromethyl)imidazo[1,2-a]pyridine
$300.00
CAS No.: 1146615-86-2
Catalog No.: 195530
Purity: 95%
MF: C8H4BrF3N2
MW: 265.032
Storage: 2-8 degree Celsius
SMILES: BrC1=CN=C2N1C=C(C=C2)C(F)(F)F
Catalog No.: 195530
Purity: 95%
MF: C8H4BrF3N2
MW: 265.032
Storage: 2-8 degree Celsius
SMILES: BrC1=CN=C2N1C=C(C=C2)C(F)(F)F
3-bromo-6-(trifluoromethyl)imidazo[1,2-a]pyridine; CAS No.: 1146615-86-2; 3-bromo-6-(trifluoromethyl)imidazo[1,2-a]pyridine. PROPERTIES: 3-bromo-6-(trifluoromethyl)imidazo[1,2-a]pyridine is a crystalline compound with molecular formula C9H5BrF3N2. It demonstrates a melting point in the range of 185-188 C and shows moderate thermal stability. The compound exhibits low solubility in most organic solvents but can be dissolved in hot DMSO or sulfolane. Recommended storage conditions include keeping it in amber glass bottles at 2-8 C to prevent photodegradation. Safety considerations involve handling in well-ventilated areas with appropriate respiratory protection due to potential release of toxic fumes upon heating. APPLICATIONS: This trifluoromethyl-containing heterocycle serves as a key intermediate in the development of BTK inhibitors for autoimmune disease treatment, where the 3-bromo-6-(trifluoromethyl)imidazo[1,2-a]pyridine scaffold contributes to kinase domain interactions (Journal of Medicinal Chemistry). In materials science, the compound's electron-deficient nature makes it suitable for incorporation into organic photovoltaic materials as an electron acceptor component (Advanced Materials). Additionally, its bromine substituent enables strategic cross-coupling reactions for the synthesis of kinase inhibitor libraries used in cancer research (Bioorganic & Medicinal Chemistry Letters).
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