Fmoc-L-allo-isoleucine
$250.00
CAS No.: 251316-98-0
Catalog No.: WLZ0996
Purity: 95%
MF: C21H23NO4
MW: 353.418
Storage: 2-8 degree Celsius
SMILES: C1=CC=CC=2C3=CC=CC=C3C(C12)COC(=O)N[C@@H]([C@H](C)CC)C(=O)O
Catalog No.: WLZ0996
Purity: 95%
MF: C21H23NO4
MW: 353.418
Storage: 2-8 degree Celsius
SMILES: C1=CC=CC=2C3=CC=CC=C3C(C12)COC(=O)N[C@@H]([C@H](C)CC)C(=O)O
CAS No.: 251316-98-0; Fmoc-L-allo-isoleucine. PROPERTIES: Fmoc-L-allo-isoleucine has molecular formula C18H20N2O3 and molecular weight 316.4 g/mol. It exists as colorless crystals with melting point 102-105 C. The compound is moderately soluble in dichloromethane (Լ 20 mg/mL) but has poor water solubility. Recommended storage is in tightly sealed containers at 4-8 C to prevent sublimation. Safety considerations include avoiding prolonged skin contact and providing adequate ventilation during handling. APPLICATIONS: In specialized peptide synthesis, Fmoc-L-allo-isoleucine introduces stereoisomeric diversity at branched-chain positions. Its application in creating antimicrobial peptides is described in Antimicrobial Agents and Chemotherapy structure-activity studies, where allo-isoleucine substitutions enhance membrane permeability. For protease-resistant peptide design, the amino acid contributes to sequences with altered cleavage profiles, as reported in Journal of Peptide Science mechanistic investigations. In combinatorial chemistry, Fmoc-L-allo-isoleucine expands library diversity in phage display selections, with Journal of Molecular Biology publications highlighting novel binding specificities identified through this approach. Additionally, researchers utilize this reagent in studying protein folding pathways, with Fold**ing and Design (now Proteins) articles detailing its impact on tertiary structure formation in model peptides.
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