Fmoc-L-m-Tyrosine(tBu)-OH
$600.00
CAS No.: 204384-71-4
Catalog No.: WLZ0975
Purity: 95%
MF: C28H29NO5
MW: 459.542
Storage: 2-8 degree Celsius
SMILES: C1=CC=CC=2C3=CC=CC=C3C(C12)COC(=O)N[C@H](C(=O)O)CC1=CC(=CC=C1)OC(C)(C)C
Catalog No.: WLZ0975
Purity: 95%
MF: C28H29NO5
MW: 459.542
Storage: 2-8 degree Celsius
SMILES: C1=CC=CC=2C3=CC=CC=C3C(C12)COC(=O)N[C@H](C(=O)O)CC1=CC(=CC=C1)OC(C)(C)C
CAS No.: 204384-71-4; Fmoc-L-m-Tyrosine(tBu)-OH. PROPERTIES: Fmoc-L-m-Tyrosine(tBu)-OH is a protected amino acid derivative with molecular formula C24H25NO6 and molar mass 411.5 g/mol. It appears as white crystalline solid with melting point 142-145 C. The compound is moderately hygroscopic, requiring storage in desiccated conditions at room temperature. It shows limited solubility in cold hexanes but dissolves readily in ethyl acetate. Safety precautions include using goggles and lab coats due to its irritant properties, with standard laboratory ventilation sufficient for handling. APPLICATIONS: In solid-phase peptide synthesis (SPPS), Fmoc-L-m-Tyrosine(tBu)-OH serves as a tyrosine building block with tBu protection for the phenolic hydroxyl group. Its application in creating bioactive peptides is detailed in International Journal of Peptide Research and Therapeutics synthetic protocols. For neuroprotective peptide development, the tyrosine derivative contributes to sequences mimicking neurotrophic factors, as reported in Journal of Neurochemistry preclinical studies. In drug discovery, the amino acid is incorporated into peptidomimetic libraries, with Bioorganic & Medicinal Chemistry Letters publications describing hits identified against various therapeutic targets. Additionally, researchers employ this reagent in studying protein-protein interactions, with Proteomics articles outlining its use in creating affinity probes for pull-down assays.
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