2-(pyrimidin-5-yl)benzaldehyde
$250.00
CAS No.: 640769-71-7
Catalog No.: 196406
Purity: 95%
MF: C11H8N2O
MW: 184.198
Storage: 2-8 degree Celsius
SMILES: N1=CN=CC(=C1)C1=C(C=O)C=CC=C1
Catalog No.: 196406
Purity: 95%
MF: C11H8N2O
MW: 184.198
Storage: 2-8 degree Celsius
SMILES: N1=CN=CC(=C1)C1=C(C=O)C=CC=C1
2-(pyrimidin-5-yl)benzaldehyde; CAS No.: 640769-71-7; 2-(pyrimidin-5-yl)benzaldehyde. PROPERTIES: This compound presents a 2-(pyrimidin-5-yl)benzaldehyde structure, combining a pyrimidine ring and a benzaldehyde moiety. It typically appears as a white to off-white crystalline solid with a molecular weight of approximately 189.2 g/mol (C11H8N2O). The melting point ranges between 120-125 C, and it exhibits moderate solubility in common organic solvents like ethyl acetate, dichloromethane, and tetrahydrofuran while being sparingly soluble in water. Proper storage requires a tightly sealed container in a cool, dry place. Safety considerations include wearing appropriate PPE. It is classified as a skin and eye irritant (GHS07) with the hazard statement H315-H319. APPLICATIONS: 2-(Pyrimidin-5-yl)benzaldehyde serves as a specialized intermediate in pharmaceutical research. Its 2-(pyrimidin-5-yl)benzaldehyde structure enables diverse reactivity patterns, including nucleophilic addition at the aldehyde carbonyl and electrophilic substitution at the pyrimidine ring. In medicinal chemistry, it is used to develop bioactive molecules targeting kinases, proteases, and G protein-coupled receptors. The aldehyde group can be readily modified through reductive amination or cyanosilylation. This compound also functions as a building block in the synthesis of fluorescent dyes and bioconjugation reagents. Academic studies utilize it as a model system in Medicinal Chemistry journals, focusing on optimizing the 2-(pyrimidin-5-yl)benzaldehyde scaffold for improved biological activity and pharmacokinetic properties.
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