2,5-dichloro-4-methylpyrimidine
$300.00
CAS No.: 1192064-63-3
Catalog No.: 196409
Purity: 95%
MF: C5H4Cl2N2
MW: 163.007
Storage: 2-8 degree Celsius
SMILES: ClC1=NC=C(C(=N1)C)Cl
Catalog No.: 196409
Purity: 95%
MF: C5H4Cl2N2
MW: 163.007
Storage: 2-8 degree Celsius
SMILES: ClC1=NC=C(C(=N1)C)Cl
2,5-dichloro-4-methylpyrimidine; CAS No.: 1192064-63-3; 2,5-dichloro-4-methylpyrimidine. PROPERTIES: This compound presents a 2,5-dichloro-4-methylpyrimidine structure, combining two chloro substituents and a methyl group on the pyrimidine framework. It typically appears as a white to off-white crystalline solid with a molecular weight of approximately 175.0 g/mol (C5H4Cl2N). The melting point ranges between 100-105 C, and it exhibits moderate solubility in common organic solvents like DMSO and DMF while being sparingly soluble in water. Proper storage requires a tightly sealed container in a cool, dry place. Safety considerations include wearing appropriate PPE. It is classified as a skin and eye irritant (GHS07) with the hazard statement H315-H319. APPLICATIONS: 2,5-Dichloro-4-methylpyrimidine serves as a specialized intermediate in pharmaceutical research. Its 2,5-dichloro-4-methylpyrimidine structure enables diverse reactivity patterns, including nucleophilic substitution at the chloro positions and electrophilic substitution at the pyrimidine ring. In medicinal chemistry, it is used to develop bioactive molecules targeting kinases, proteases, and G protein-coupled receptors. The dichloro substituents provide handles for introducing aryl, vinyl, or heterocyclic substituents. This compound also functions as a building block in the synthesis of fluorescent dyes and bioconjugation reagents. Academic studies utilize it as a model system in Medicinal Chemistry journals, focusing on optimizing the 2,5-dichloro-4-methylpyrimidine scaffold for improved biological activity and target engagement.
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