2-amino-5-bromo-6-phenylpyrimidin-4-ol
$400.00
CAS No.: 56741-95-8
Catalog No.: 196411
Purity: 95%
MF: C10H8BrN3O
MW: 266.098
Storage: 2-8 degree Celsius
SMILES: NC1=NC(=C(C(=N1)O)Br)C1=CC=CC=C1
Catalog No.: 196411
Purity: 95%
MF: C10H8BrN3O
MW: 266.098
Storage: 2-8 degree Celsius
SMILES: NC1=NC(=C(C(=N1)O)Br)C1=CC=CC=C1
2-amino-5-bromo-6-phenylpyrimidin-4-ol; CAS No.: 56741-95-8; 2-amino-5-bromo-6-phenylpyrimidin-4-ol. PROPERTIES: This compound presents a 2-amino-5-bromo-6-phenylpyrimidin-4-ol structure, combining an amino group, a bromine atom, and a phenyl group on the pyrimidine framework. It typically appears as a white to off-white crystalline solid with a molecular weight of approximately 271.1 g/mol (C11H8BrN3O). The melting point ranges between 170-175 C, and it exhibits moderate solubility in common organic solvents like DMSO and DMF while being sparingly soluble in water. Proper storage requires a tightly sealed container in a cool, dry place. Safety considerations include wearing appropriate PPE. It is classified as a skin and eye irritant (GHS07) with the hazard statement H315-H319. APPLICATIONS: 2-Amino-5-bromo-6-phenylpyrimidin-4-ol serves as a specialized intermediate in pharmaceutical research. Its 2-amino-5-bromo-6-phenylpyrimidin-4-ol structure enables diverse reactivity patterns, including nucleophilic substitution at the bromo position and hydrogen bonding interactions through the hydroxyl group. In medicinal chemistry, it is used to develop bioactive molecules targeting kinases, proteases, and G protein-coupled receptors. The phenyl group provides additional conjugation that enhances binding to biological targets. This compound also functions as a building block in the synthesis of fluorescent dyes and bioconjugation reagents. Academic studies utilize it as a model system in Medicinal Chemistry journals, focusing on optimizing the 2-amino-5-bromo-6-phenylpyrimidin-4-ol scaffold for improved biological activity and target engagement.
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