2-amino-4-methylpyrimidine-5-carbonitrile
$200.00
CAS No.: 17321-97-0
Catalog No.: 196410
Purity: 95%
MF: C6H6N4
MW: 134.142
Storage: 2-8 degree Celsius
SMILES: NC1=NC=C(C(=N1)C)C#N
Catalog No.: 196410
Purity: 95%
MF: C6H6N4
MW: 134.142
Storage: 2-8 degree Celsius
SMILES: NC1=NC=C(C(=N1)C)C#N
2-amino-4-methylpyrimidine-5-carbonitrile; CAS No.: 17321-97-0; 2-amino-4-methylpyrimidine-5-carbonitrile. PROPERTIES: This compound features a 2-amino-4-methylpyrimidine-5-carbonitrile structure, combining an amino group, a methyl substituent, and a nitrile group on the pyrimidine framework. It typically appears as a white to off-white crystalline solid with a molecular weight of approximately 143.1 g/mol (C6H7N3). The melting point ranges between 130-135 C, and it exhibits moderate solubility in common organic solvents like ethanol, methanol, and DMSO while being sparingly soluble in water. Proper storage requires a tightly sealed container in a cool, dry place. Safety considerations include wearing appropriate PPE. It is classified as a skin and eye irritant (GHS07) with the hazard statement H315-H319. APPLICATIONS: 2-Amino-4-methylpyrimidine-5-carbonitrile serves as a versatile intermediate in pharmaceutical and chemical synthesis. Its 2-amino-4-methylpyrimidine-5-carbonitrile structure allows for participation in various reactions, including nucleophilic substitution at the pyrimidine ring and amine bond formation. In medicinal chemistry, it is used to develop bioactive molecules targeting kinases, proteases, and G protein-coupled receptors. The nitrile group can be hydrolyzed to a carboxylic acid or reduced to an amine for further functionalization. This compound also functions as a building block in the synthesis of fluorescent dyes and bioconjugation reagents. Academic studies employ it as a model compound in Medicinal Chemistry journals, focusing on optimizing the 2-amino-4-methylpyrimidine-5-carbonitrile scaffold for improved biological activity and pharmacokinetic properties.
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