8-(trifluoromethoxy)quinoline-5-carboxylic acid
$400.00
CAS No.: 2241594-63-6
Catalog No.: 192188
Purity: 95%
MF: C11H6F3NO3
MW: 257.167
Storage: 2-8 degree Celsius
SMILES: FC(OC1=CC=C(C=2C=CC=NC12)C(=O)O)(F)F
Catalog No.: 192188
Purity: 95%
MF: C11H6F3NO3
MW: 257.167
Storage: 2-8 degree Celsius
SMILES: FC(OC1=CC=C(C=2C=CC=NC12)C(=O)O)(F)F
8-(trifluoromethoxy)quinoline-5-carboxylic acid; CAS No.: 2241594-63-6; 8-(trifluoromethoxy)quinoline-5-carboxylic acid. PROPERTIES: 8-(trifluoromethoxy)quinoline-5-carboxylic acid is a white crystalline powder with molecular weight 235.14 g/mol. It has a melting point of approximately 205-210 C and demonstrates pH-dependent solubility with better dissolution in basic aqueous solutions. The compound should be stored in a vacuum desiccator at -20 C to prevent moisture-induced degradation. Safety considerations include using a fume hood during handling due to its potential to release irritating vapors, along with standard protective equipment. APPLICATIONS: This compound is utilized in the synthesis of HIV integrase inhibitors where the trifluoromethoxy group enhances enzyme binding affinity as described in antiviral research papers. The carboxylic acid functionality allows for amide bond formation, making it suitable for creating peptide mimetics. Additionally, 8-(trifluoromethoxy)quinoline-5-carboxylic acid derivatives have found use in bioanalytical chemistry as fluorescent probes for detecting specific metal ions. According to analytical chemistry journals, the quinoline scaffold provides a fluorescent response upon metal coordination, enabling sensitive detection methods.
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