8-(trifluoromethoxy)quinolin-3-ol
$300.00
CAS No.: 1261886-64-9
Catalog No.: 192198
Purity: 95%
MF: C10H6F3NO2
MW: 229.157
Storage: 2-8 degree Celsius
SMILES: FC(OC=1C=CC=C2C=C(C=NC12)O)(F)F
Catalog No.: 192198
Purity: 95%
MF: C10H6F3NO2
MW: 229.157
Storage: 2-8 degree Celsius
SMILES: FC(OC=1C=CC=C2C=C(C=NC12)O)(F)F
8-(trifluoromethoxy)quinolin-3-ol; CAS No.: 1261886-64-9; 8-(trifluoromethoxy)quinolin-3-ol. PROPERTIES: 8-(trifluoromethoxy)quinolin-3-ol is a pale yellow solid with molecular formula C10H6F3N2O. It has a melting point between 105-110 C and shows solubility in polar organic solvents while being practically insoluble in water. Proper storage involves maintaining under nitrogen atmosphere at 5-15 C to prevent oxidation. Safety considerations include avoiding contact with strong bases and using protective equipment as this compound may cause serious eye damage. APPLICATIONS: This trifluoromethoxy-substituted quinoline derivative is employed in the synthesis of kinase inhibitors. The hydroxyl group provides a site for PEGylation, enhancing the pharmacokinetic properties of the molecule as described in cancer research literature. In bioanalytical chemistry, 8-(trifluoromethoxy)quinolin-3-ol serves as a fluorescent probe for detecting specific enzyme activities. According to biochemical journals, the quinoline scaffold's fluorescence is quenched upon enzyme-catalyzed cleavage, enabling real-time monitoring of enzymatic reactions.
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