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3-bromo-8-(trifluoromethoxy)quinoline; CAS No.: 2241594-65-8; 3-bromo-8-(trifluoromethoxy)quinoline. PROPERTIES: 3-bromo-8-(trifluoromethoxy)quinoline is a crystalline material with molecular formula C9H5BrF3N2. It has a melting point between 78-82 C and exhibits low water solubility while being soluble in common organic solvents like dichloromethane and acetone. Proper storage requires an airtight container in a dark, cool place (ideally 15-25 C). Safety precautions include using spark-proof tools and avoiding contact with oxidizing agents due to its flammability, along with standard laboratory PPE to prevent skin absorption. APPLICATIONS: This halogenated quinoline derivative is primarily used in the development of antimicrobial agents. The combination of bromine and trifluoromethoxy substituents creates a privileged structure for inhibiting bacterial topoisomerases as reported in antimicrobial research journals. In materials science, 3-bromo-8-(trifluoromethoxy)quinoline serves as a building block for creating electron-transport materials in organic photovoltaics. According to materials chemistry publications, the electron-withdrawing trifluoromethoxy group improves charge transport properties while the bromine provides sites for further functionalization.