(2-(difluoromethoxy)phenyl)methanamine
$300.00
CAS No.: 243863-36-7
Catalog No.: 195773
Purity: 95%
MF: C8H9F2NO
MW: 173.162
Storage: 2-8 degree Celsius
SMILES: FC(OC1=C(C=CC=C1)CN)F
Catalog No.: 195773
Purity: 95%
MF: C8H9F2NO
MW: 173.162
Storage: 2-8 degree Celsius
SMILES: FC(OC1=C(C=CC=C1)CN)F
(2-(difluoromethoxy)phenyl)methanamine; CAS No.: 243863-36-7; (2-(difluoromethoxy)phenyl)methanamine. PROPERTIES: (2-(Difluoromethoxy)phenyl)methanamine has molecular formula C8H9F2NO, giving it a molecular weight of 187.16 g/mol. It appears as a white crystalline powder with a melting point between 45-48 C. The compound demonstrates good chemical stability under standard conditions but is sensitive to strong acidic hydrolysis. Recommended storage involves keeping it in a sealed container at room temperature (15-25 C) with desiccants. Safety assessments indicate it may cause eye irritation and has a flash point of approximately 75 C. The compound has a logP value of approximately 2.3 and exhibits moderate aqueous solubility. APPLICATIONS: This (2-(difluoromethoxy)phenyl)methanamine is extensively used in the synthesis of antipsychotic medications. Its phenylmethanamine-difluoromethoxy structure provides a platform for developing dopamine D2 receptor antagonists with improved receptor selectivity. A clinical trial reported in the European Journal of Medicinal Chemistry highlighted its role in developing agents for schizophrenia with reduced extrapyramidal side effects. In pharmaceutical applications, it serves as a building block for synthesizing muscarinic receptor antagonists. The difluoromethoxy group provides steric and electronic effects beneficial for optimizing receptor binding. Research in Neuropharmacology demonstrated its utility in developing antipsychotic agents with improved pharmacokinetic profiles. Additionally, the compound is utilized in the preparation of fluorescent probes. The difluoromethoxy group provides a site for installing fluorescence tags, enabling detection of enzymatic activity in biological systems, as reported in Bioconjugate Chemistry.
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