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Fmoc-Phe(4-me)-OH; (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(p-tolyl)propanoic acid; CAS No.: 199006-54-7; Fmoc-Phe(4-me)-OH. PROPERTIES: Fmoc-Phe(4-me)-OH is a protected amino acid derivative used in peptide synthesis. This compound has a molecular weight of 344.40 g/mol and appears as a white to off-white solid. It demonstrates limited water solubility but is soluble in common organic solvents. Fmoc-Phe(4-me)-OH should be stored at room temperature in a dry, dark environment. It is sensitive to moisture and light. Safety considerations include potential eye and skin irritation, so protective equipment is recommended. APPLICATIONS: Fmoc-Phe(4-me)-OH serves as a building block in the synthesis of peptides containing 4-methylphenylalanine residues. In medicinal chemistry, it facilitates the creation of peptidomimetics with altered hydrophobic properties and conformational preferences. In research applications, Fmoc-Phe(4-me)-OH is used to prepare peptides for studying protein-protein interactions and receptor binding. These applications are described in peptide synthesis protocols and medicinal chemistry literature.