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Fmoc-D-Ser(tBu)-OH; (R)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-tert-butoxypropanoic acid; CAS No.: 128107-47-1; Fmoc-D-Ser(tBu)-OH. PROPERTIES: Fmoc-D-Ser(tBu)-OH is a protected amino acid derivative used in peptide synthesis. This compound has a molecular weight of 328.39 g/mol and appears as a white to slightly yellowish solid. It is sparingly soluble in water but dissolves in organic solvents like DMF and dichloromethane. Fmoc-D-Ser(tBu)-OH should be stored at room temperature in a dry environment. It is sensitive to moisture and light. Safety precautions include avoiding inhalation and skin contact as it may cause irritation. APPLICATIONS: Fmoc-D-Ser(tBu)-OH serves as a monomer in the synthesis of peptides containing D-serine residues with Fmoc protection on the amino group and tBu protection on the hydroxyl group. In medicinal chemistry, it facilitates the creation of peptidomimetics with enhanced stability and bioavailability. In research applications, Fmoc-D-Ser(tBu)-OH is used to prepare peptides for studying protein conformation and enzyme inhibition. These applications are referenced in peptide chemistry literature and synthetic organic chemistry publications.