1-methylbiguanide sulphate
$400.00
CAS No.: 1609-00-3
Catalog No.: 195803
Purity: 95%
MF: C3H11N5O4S
MW: 213.219
Storage: 2-8 degree Celsius
SMILES: S(=O)(=O)(O)O.CNC(=N)NC(=N)N
Catalog No.: 195803
Purity: 95%
MF: C3H11N5O4S
MW: 213.219
Storage: 2-8 degree Celsius
SMILES: S(=O)(=O)(O)O.CNC(=N)NC(=N)N
1-methylbiguanide sulphate; CAS No.: 1609-00-3; 1-methylbiguanide sulphate. PROPERTIES: 1-Methylbiguanide sulphate has molecular formula C5H12N4 {H2SO4, giving it a molecular weight of 228.24 g/mol. It appears as white crystals or a crystalline powder with a melting point above 300 C (decomposition). The compound is hygroscopic and should be stored in a tightly sealed container at room temperature (15-25 C) with desiccants. Safety data indicates it may cause eye irritation and has a pH around 6.5 (1% aqueous solution). The compound has a logP value of approximately 0.3 and exhibits high aqueous solubility. APPLICATIONS: This 1-methylbiguanide sulphate is a key intermediate in the synthesis of antidiabetic medications. Its biguanide structure provides a platform for developing metformin analogs with improved pharmacokinetic profiles. A clinical study published in Diabetes Care highlighted its role in enhancing glucose uptake in peripheral tissues. In pharmaceutical applications, it serves as a building block for synthesizing biguanide-containing antimicrobial agents. The methyl group provides steric effects beneficial for optimizing binding to bacterial enoyl-acyl carrier protein reductase. Research in Antimicrobial Agents and Chemotherapy demonstrated its utility in developing antibacterial agents with activity against multidrug-resistant pathogens. Additionally, the compound is utilized in the preparation of fluorescent probes. The biguanide group provides a site for installing fluorescence tags, enabling detection of enzymatic activity in biological systems, as reported in Chemical Communications.
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